- 2300 AD by Game Designers' Workshop
- The 23rd Letter by Crucible Design - a modern day game of psychics and conspiracies
- 3D&T by Talismã - a Brazilian generic system, turned to anime-style campaigns
- a/state by Contested Ground Studios
- Aberrant by White Wolf, Inc. - super-hero characters in the near future, part of the Trinity series
- Absolute Zero by Undecided Studios - Freeform customizable system
- Action! System by Gold Rush Games - a generic open gaming system with a cinematic feel, similar to Fuzion
- Advanced Dungeons & Dragons - see also Dungeons & Dragons
- Adventure! by White Wolf, Inc. - a pulp adventure, part of the Trinity series
- The Adventures of Indiana Jones Role-Playing Game by TSR, Inc.
- Adventurers of the North - Kalevala Heroes (a.k.a. ANKH)
- After The Bomb by Palladium Books
- Aftermath! by Fantasy Games Unlimited
- Against the Darkness by Tabletop Adventures, LLC - Vatican Conspiracy and Horror
- Agone (French) - edited in French by Multisim Editions and translated in English by Multisim Editions
- AIF by NastiDyne - a free SF RPG
- Albedo - Based on the furry comic book series, Erma Felna by Steve Gallacci
- Algonquin Wilderness School - a play-by-post RPG about a modern wilderness school for troubled teens
- Aliens by Leading Edge Games
- All Flesh Must Be Eaten by Eden Studios, Inc. - Zombie survival horror game
- Alpha Omega: The Beginning and The End by Mind Storm Labs, LLC
- Alshard (Japanese) - fantasy with mecha like Final Fantasy
- Alshard Gaia (Japanese) - a contemporary fantasy with Alshard system
- Alternate Worlds RPG by Alternate Worlds Publishing
- Alternity by TSR, Inc.
- Amazing Engine by TSR, Inc.
- Amber Diceless Roleplaying - based on the works of Roger Zelazny
- Anima: Beyond Fantasy - a collaboration of Eastern and Western developers RPG with anime-style artworks
- Angel - a spin-off of the Buffy the Vampire Slayer game
- Arduin by David A. Hargrave - the first cross-genre RPG
- Aria
- Arianrhod RPG (Japanese) - MMORPG-like
- Arkéos by Extraordinary Worlds Studio - Pulp adventure
- Ars Magica by Lion Rampant (editions 1 & 2), White Wolf, Inc. (edition 3), Atlas Games (editions 4 & 5)
- AssassinX by E.N. Publishing - violent adventure
- Atlantis: The Second Age - by Morrigan Press
- Avant Charlemagne by François Nédelec (French) - early Middle-Age
- Axiom16 (Bulgarian)
- Babylon 5 by Mongoose Publishing
- Babylon Project - Based on the Babylon 5 TV franchise
- Basic Role-Playing by Chaosium - role-playing game system
- Battleaxe by Sixteen Coal Black Horses - fantasy role-playing
- BattleDragons by Spartacus Publishing - play as dragons in a fantasy world
- Battlelords of the 23rd Century by SSDC, Inc.
- Battlestar Galactica Role Playing Game by Margaret Weis Productions, Ltd - based on the SciFi TV series
- Beyond the Supernatural
- Big Bang Comics RPG
- Big Eyes, Small Mouth by Guardians of Order - anime-based RPG
- Bitume by Croc (French - post-apocalyptic, Mad Max-like)
- Bliss Stage by TAO games - Mecha game taking place 7 years after the adults of the world fell asleep
- Blood Dawn by SSDC, Inc.
- Blood of Heroes
- Bloodlust (French), edited by Asmodée Editions
- Blue Planet by Biohazard Games
- Blue Rose by Green Ronin
- Boot Hill by TSR, Inc. - Wild West adventure
- Buffy the Vampire Slayer - based on the TV show of the same name
- Bunnies and Burrows
- Bureau 13: Stalking the Night Fantastic by Tri Tac Games
- The Burning Wheel - high fantasy
- Bushido by Fantasy Games Unlimited - samurai RPG
- Cadwallon by Rackham
- Call of Cthulhu by Chaosium - based on the works of H. P. Lovecraft
- Cartoon Action Hour by Spectrum Games
- Castles & Crusades by Troll Lord Games - OGL System fantasy RPG
- Castle Falkenstein - steampunk fantasy
- Catgirl Avengers - Furry/anime humor RPG
- Champions by Hero Games
- Changeling: The Dreaming (original World of Darkness)
- Changeling: The Lost (new World of Darkness)
- Children of the Sun by Misguided Games
- Chill
- Chivalry and Sorcery
- Chronicles System - Steampunk fantasy, Freely distributed skill-based d100 system
- Les Chroniques d'Erdor, edited by Boite a Polpette - an unusual French RPG of oneiric fantasy using a 54 card deck
- Circe by Bryce Harrington
- City of Heroes by Eden Studios, Inc. - the tabletop companion to the City of Heroes MMORPG.
- Cliffhanger by Fantasy Games Unlimited - 1930s adventure
- La Compagnie de glaces (French) - post-apocalyptic, from the novels of G.-J. Arnaud
- Cold City by Contested Ground Studios
- Conan Role-playing Game by TSR, Inc., a GURPS game by Steve Jackson Games, and an OGL System game by Mongoose Publishing
- Conspiracy X by Eden Studios, Inc. - extraterrestrials, UFOs, and government coverups
- Contenders by Prince of Darkness Games - award winning game revolving around the lives of boxers
- C°ntinuum - time travel adventure
- Core Command by Dream Pod 9
- Corporation the Roleplaying Game by Core Games Publishing
- CORPS by Blacksburg Tactical Research Center
- Corum - an addendum to the Stormbringer RPG (aka Elric!)
- Cosmic Synchronicity by Joseph Teller
- Covenant by Realms Publishing
- CthulhuTech by Wildfire, this is H.P. Lovecraft's horror with Mecha and Anime influences.
- Cursed Empire by Chris Loizou - dark fantasy. Formerly known as Crimson Empire
- Cybergeneration by R. Talsorian Games - alternate setting for Cyberpunk 2020
- Cyberpunk 2013 by R. Talsorian Games - out of print and superseded by Cyberpunk 2020
- Cyberpunk 2020 by R. Talsorian Games - based on the mirror shades authors
- Cyberpunk 203X by R. Talsorian Games
- Cyberspace by Iron Crown Enterprises
- Cyborg Commando by New Infinities, Inc.
- Cyno's Role-Play
- D6 System by West End Games - in-house system, based on the Star Wars RPG
- d20 Future by Wizards of the Coast - generic futuristic game using the d20 System
- d20 Modern by Wizards of the Coast - generic modern game using the d20 System
- d20 Past by Wizards of the Coast - generic historical game using the d20 System
- d20 System - based on Dungeons & Dragons 3rd Edition rules
- Danger International by Hero Games - espionage adventure
- Dangerous Journeys by E. Gary Gygax, published by Game Designers' Workshop
- Daredevils - pulp era mystery
- Dash-in Dungeons by Wednesday Night Games - fast-play fantasy RPG
- Dark Conspiracy by Games Designers' Workshop
- Dark Continent - colonial African horror
- The Dark Eye - Germany's most popular RPG, known in Germany as Das Schwarze Auge
- Dark Heresy, the Warhammer 40,000 Roleplay Game by Black Industries
- DC Heroes by Mayfair Games
- DC Universe Roleplaying Game by West End Games
- Dead Inside - a small-press RPG where the characters attempt to rebuild their lost souls through selfless and noble actions (and get superhuman powers along the way)
- Deadlands: Lost Colony by Pinnacle Entertainment Group
- Deadlands: The Weird West by Pinnacle Entertainment Group, GURPS version by SJGames
- Deeds of Valor by Swordmaster
- Deliria: Faerie Tales for the New Millennium by Phil Brucato, published by Laughing Pan Productions
- Demon: The Fallen (original World of Darkness)
- Diana: Warrior Princess by Marcus Rowland
- Diomin by OtherWorld Creations
- The Doctor Who Role Playing Game by FASA - based on the 1963-89 run of the BBC television series
- Doctor Who (role-playing game) by Cubicle 7 Entertainment Ltd - based on the 2005-Present BBC television series
- Dogs in the Vineyard by Lumpley Games - loosely based on the Mormon State of Deseret in pre-statehood Utah
- Dominion Rules - an open-source fantasy twelve-sided-die-based RPG encouraging the creation of new skill, spells, beasts and rules and featuring an innovative combat system
- Donjon by Clinton R. Nixon, Donjon Anvilwerks
- Don't Rest Your Head by Evil Hat Productions
- Double Cross - Superhero (Japanese)
- DragonMech - a cross between fantasy and mecha
- DragonNet - a free open-source fantasy RPG system
- DragonQuest - a now out-of-print RPG, suppressed by TSR
- DragonRaid by Dick Wulf - a Christian RPG
- Dragonstar - where science fiction and fantasy blend
- Dragon Warriors - an easy-to-use RPG system published in paperback format
- Drakar och Demoner (Dragons and Demons) - Swedish fantasy RPG
- Draug - Norwegian RPG set in 1801, based on the FUDGE engine.
- Dread: The First Book of Pandemonium by Rafael Chandler
- Dreaming Cities - an urban fantasy game by Guardians of Order for the Tri-Stat system
- Duelist System by Undecided Studios - Martial Arts role-playing system
- Dungeons & Dragons - created by Dave Arneson and E. Gary Gygax, further editions by TSR, Inc. and Wizards of the Coast
- Dying Earth - based on the stories of Jack Vance
- Dzikie Pola (Wild Fields), a set in 17th century Polish-Lithuanian Commonwealth
- EABA, or End All Be All by Blacksburg Tactical Research Center - a generic RPG system
- Earthdawn
- Elemental Axes by Crosstime Games
- Elfquest by Chaosium - based on the works of Richard Pini and Wendy Pini
- Elric! by Chaosium, based on Michael Moorcock's Elric of Melniboné stories
- En Garde! by Game Designers' Workshop and SFC Press - duelists from 17th century France
- Endyval - (Bulgarian) Sivosten
- Empire Galactique by François Nédelec (French) - space opera
- Empire of the Petal Throne - set in M. A. R. Barker's world of Tékumel
- Eon by NeoGames - Swedish fantasy game
- Epic Role Playing by Dark Matter Studios
- Epoch Star
- ERA by Clinica TBF
- E-RPG System by Ironwood Omnimedia
- Espionage! by Hero Games - based on Second Edition Champions
- Etherlords by Nival Interactive
- Etherscope by Goodman Games
- EverQuest Role-Playing Game by White Wolf, Inc. - pencil & paper version of the popular MMORPG
- Everway
- EW-System by Extraordinary Worlds Studio - Open game system
- Ex Machina
- Exalted
- Exile (MUD)
- EXO by Ediciones Sombra)(Spanish
- The Extraordinary Adventures of Baron Münchhausen by James Wallis - a storytelling RPG based on the novel of Baron Münchhausen
- Fading Suns
- Faery's Tale by Firefly Games - an interactive storytelling game of fairy folklore suitable for younger players
- Fairy Meat by Kenzer & Company
- Fanhunter - Spanish game based on the series of comics of the same name
- Fantasy Hero
- Fantasy Imperium by Shadowstar Games, Inc. - an interactive storytelling game of historical fantasy
- The Fantasy Trip by Steve Jackson, published by Metagaming Concepts
- The Fantasy Sagas - A Player's Guidebook for Ironwood Omnimedia E-RPG System
- Fantasy Wargaming - a project by dissatisfied British Dungeons & Dragons players, it was considered incomplete and insufficient yet featured noteworthy elements and qualities that are still yet unseen in most role-playing games
- Farscape Roleplaying Game by Alderac Entertainment Group
- Fastlane by Twisted Confessions author Alexander Cherry
- FATE - Fantastic Adventures in Tabletop Entertainment based on the FUDGE engine
- Fates Worse Than Death by Vajra Enterprises - a cyberpunk-influenced game set in Manhattan in 2080
- Father RPG - An unofficial RPG
- Feng Shui - based on Hong Kong martial arts movies
- Fight the Evil Power - a role-playing game designed for people who haven't played before
- Fightsystem.com
- Fireborn by Fantasy Flight Games
- Forgotten Futures
- Friendly Wars by Undecided Studios
- Fringeworthy by Tri Tac Games
- FTL:2448 by Tri Tac Games
- FUDGE by Steffan O'Sullivan - "Free, Universal, Do-it-Yourself Gaming Engine"
- Furry Outlaws
- Furry Pirates
- Fuzion by R. Talsorian Games and Hero Games - a simple and customizable generic open gaming system co-produced , based on principles from R. Talsorian's Interlock System and Hero Games' Hero System
- A Game of Thrones - based on the eponymous fantasy novel
- Gamma World by TSR, Inc.
- Gangbusters by TSR, Inc. - 1930s urban crime adventure
- Ganghedge by Empire Wargames
- Gatecrasher - a tongue-in-cheek science-fiction & fantasy setting
- Gaterunner - based on the novel Gatecrash
- Ghostbusters by West End Games - based on the Ghostbusters film series
- God of War
- Godlike byHawthorn Hobgoblynn Press
- Golden Heroes by Games Workshop
- The Great Commission - a d20 Christian RPG
- Grimm
- GURPS by Steve Jackson Games - "Generic Universal Role Playing System"
- HackMaster by Kenzer & Company
- Halcyon by Neuwerld Studios
- HardNova II
- HârnMaster/Hârn
- HARP by Iron Crown Enterprises - "High Adventure Role-Playing"
- HARPE - the "Hugely Adaptable (action/anime) Role-Playing Engine", Free and quite adaptable
- Hawkmoon - an addendum to the Stormbringer RPG (aka Elric!)
- Heavy Gear by Dream Pod 9
- Heretics by Wasteland Games - modern-day horror
- Hero System by Hero Games
- Hero Wars/HeroQuest
- Heroes Unlimited by Palladium Books
- Hong Kong Action Theater
- Human Occupied Landfill
- Hunter: The Reckoning (original World of Darkness)
- Icar by Rob Lang
- Imagine Role Playing
- Ironhedge by Empire Wargames
- In Dark Alleys by Vajra Enterprises
- In Nomine - based on In Nomine Satanis / Magna Veritas
- In Nomine Satanis / Magna Veritas (French) by Croc (Siroz) - satiric gang/spy wars involving angels and demons in the contemporary world
- Incursion by Tri Tac Games
- InSpectres by Memento Mori Theatricks
- Iron Kingdoms by Privateer Press
- Iron Gauntlets: Heroic Fantasy Roleplaying
- Ironclaw - edited by Sanguine Productions Ltd
- Iron Heroes - d20 system based on making D&D playable without magic
- Jadeclaw - edited by Sanguine Productions Ltd
- Jags
- James Bond 007 by Victory Games - based on the James Bond films
- Jorune (or Skyrealms of Jorune)
- Jovian Chronicles by Dream Pod 9
- Judge Dredd: The Role-playing Game by Games Workshop, another by Mongoose Publishing
- Justice, Inc. by Hero Games - 1930s Pulp fiction oriented adventure
- Kalmo - Finnish zombie rpg
- Kindred of the East (spinoff of Vampire: The Masquerade)
- Kindred of the Ebony Kingdom(spinoff of Vampire: The Masquerade)
- Killer by Steve Jackson Games (live action)
- kill puppies for satan (sic) by Lumpley Games
- Kobolds Ate My Baby! by 9th Level Games
- Krysztaly czasu (Polish, Crystals of Time) by MAG
- Kult - Swedish game based on Gnostic concepts with some Kabbalistic undertones
- Lace and Steel, published originally by TAGG and re-released by Pharos Press - an Australian RPG set in a world of civilised Centaurs and Harpies with a musketeers/swashbuckling feel
- Lands of Adventure
- Legend of the Five Rings Role-Playing Game by Alderac Entertainment Group - Asian-themed RPG
- Légendes Celtiques (French)
- Légendes de la Vallée des rois - French RPG set in Ancient Egypt
- Legendy Armandie by Skaven - fantasy RPG created
- Legionnaire by FASA - standalone role-playing game for the Renegade Legion universe
- Lejendary Adventure, created by Gary Gygax and published by Hekaforge Productions
- Lightspeed by Christian Conkle - an overtly generic space opera RPG, using the Instant Fuzion ruleset
- Little Fears - The Role-playing Game of Childhood Terror by Key 20 Publishing
- Live Free or Die, the Game of Suburban Insurgency - a post UN invasion RPG written by an Army officer and Iraq veteran
- Living Steel by Leading Edge Games - futuristic game on the world of Rhand
- Lone Wolf
- The Lord of the Rings Roleplaying Game by Decipher, Inc. - based on the fantasy works of J. R. R. Tolkien
- Lords of Creation by Avalon Hill
- Luminary:Rise of Goonzu by Ndoors corporation, distributed by NHNco
- Macho Women with Guns by Blacksburg Tactical Research Center
- Maelstrom by Puffin Books
- Mage: The Ascension by White Wolf, Inc. - set in the original World of Darkness
- Mage: The Awakening by White Wolf, Inc. - set in the new World of Darkness 2.0
- M.A.G.U.S. (Hungarian)
- Maji by Wasteland Games - modern-day alien conspiracy game
- Man, Myth & Magic by Yaquinto - RPG drawing on 4000 B.C. to 1000 A.D. Earth legends
- Marvel Super Heroes Role-Playing Game by TSR, Inc.
- Marvel Universe Roleplaying Game by Marvel Publishing Group
- Masterbook
- Mecha - a game based on Anime Mecha science fiction
- Mechamorphosis by Fantasy Flight Games
- Mechanical Dream
- The Mechanoid Invasion
- MechWarrior
- Mega - les Messagers Galactiques (French) - parallel universe
- Megaverse by Palladium Books
- Meikyu kingdom (Japanese) - members of tiny kingdom's court explore dungeons
- Mekton by R. Talsorian Games - based on Anime Mecha science fiction
- Merc 2000 - Twilight 2000 updated for the post-Cold War '90s
- Mercenaries, Spies and Private Eyes by Flying Buffalo
- The Metabarons Roleplaying Game by West End Games
- Metamorphosis Alpha (1976)
- Middle Earth Role Play - based on the fantasy works of J. R. R. Tolkien
- Midgard - the oldest German fantasy RPG
- Miles Christi (French) - (Crusades and knights Templar)
- Mind Games RPG - by Deiron e Yangsmoth
- The Modern Sagas - A Player's Guidebook for Ironwood Omnimedia Company's E-RPG System
- Moira - Fantasy role-play with free online resources
- Monastyr (Polish), Monastery by Portal
- The Morrow Project
- Moros: world of fantasy
- MOU: Misadvetnures of Unhappyland
- Multiverser by E.R. Jones and M. Joseph Young
- Mummy: The Resurrection (original World of Darkness)
- Murphy's World by Peregrine Creative Services
- Mutant by Target Games
- Mutant Undergångens Arvtagare by Järnringen Förlag AB
- Mutant RYMD
- Mutant Chronicles
- Mutants and Masterminds by Green Ronin Publishing
- My Life with Master by Half Meme Press
- Myrskyn aika by Mike Pohjola
- Mystic Realms
- The Nearside Project by Nearside Games - adventure between 13 alternate Earths while avoiding insanity
- NeoKosmos (in Portuguese) by Krypteia Estúdio Criativo - a setting of Greek Mythology
- Neiyar: Land of Heaven and the Abyss by Bards and Sages
- Nephilim by Chaosium - modern occult
- Neuroshima (Polish) by Portal
- Nightbane
- Nightlifeby Stellar Games
- Night Wizard! (Japanese) - wizards in contemporary
- Ninja Burger by Steve Jackson Games
- Ninjas and Superspies by Palladium Books - martial arts and espionage adventure
- Nobilis by R. Sean Borgstrom
- Noir by Archon Gaming, Inc.
- Obsidian - The Age of Judgement by Apophis Consortium
- Over the Edge by Atlas Games
- Paladin
- Palladium Fantasy Role-Playing Game by Palladium Books
- Pandemonium! by MIB Productions - roleplaying in the world of tabloid news
- Pantheon role playing game
- Paper Computer Games - a series of illustrated roleplaying games with simple rules and a complex universe. Any gaming session played by anyone at any time is added to the overall storyline and considered canon.
- Paranoia originally by West End Games, later by Mongoose Publishing - a satire of dystopian futures
- Pax Draconis by Technicraft Design - a detailed rules heavy space opera with a percentile system
- Pendragon (or King Arthur Pendragon) - Arthurian legend
- Phoenix Command by Leading Edge Games
- Point Blank by Wasteland Games - modern-day Action movie game
- The Pokéthulhu Adventure Game by Cumberland Games and Diversions
- Powers and Perils by Avalon Hill
- PowerGame
- Praedor - based on the eponymous comics by Petri Hiltunen
- Prime Directive by Task Force Games
- Prince Valiant by Chaosium
- Privateers and Gentlemen by Fantasy Games Unlimited - naval adventure in the Napoleonic era
- Promethean: The Created by White Wolf, Inc. (new World of Darkness)
- Psiworld by Fantasy Games Unlimited - SF adventures with a focus on psi abilities
- Puppetland
- Q10
- QAGS
- Qin
- Quest of the Ancients
- Rangers of Taradoin by Sean-Robert Shaw
- Rapture: The Second Coming by William Spencer-Hale, Quintessential Mercy
- Recon by Palladium Books - Vietnam War adventure
- Red Dwarf: The Role Playing Game by deep 7 - based on BBC comedy Red Dwarf
- Reich Star by Simon Bell and Ken Richardson (1991) as Creative Encounters - fight Nazis in space.
- Rêve: the Dream Ouroboros by Denis Gerfaud (French, Rêve de Dragon)
- The Riddle of Steel by Driftwood Publishing
- Rifts by Palladium Games - crossover system
- Ringworld by Chaosium
- Risus
- Robotech by Palladium Games; based on the Robotech anime television series
- Rocky and Bullwinkle
- RMSS (Rolemaster Fantasy Role Playing) by Iron Crown Enterprises - fully expandable and customizable rules system
- Rules to Live By from Interactivities Ink - generic customizable live action rules system, with expansions for horror and fantasy
- Rune Striders
- Runebearer by Chris Magoun - "Magic and religion clash in a ruined world"
- RuneQuest by Chaosium, versions also by Avalon Hill and Mongoose Publishing
- Saga A Swedish fantasy role-playing game.
- Savage Worlds
- The Sci-Fi Sagas - A Player's Guidebook for Ironwood Omnimedia Company's E-RPG System
- Scion: Hero Modern day children of the gods by White Wolf
- Sengoku (role-playing game) by Gold Rush Games Historical fantasy set in feudal Japan.
- Serenity by Margaret Weis Productions, Ltd, based on the Firefly television series.
- Seventh Sea by Alderac Entertainment Company
- Shab-al-Hiri Roach by Bully Pulpit Games
- Shadowforce Archer by Alderac Entertainment Group - a setting for Spycraft
- Shadow Nations (Obsidian Europe Horror, Scifi, fantasy)
- Shadowrun (cyberpunk fantasy)
- Shatterzone
- Silver Age Sentinels by Guardians of Order
- Simply Roleplaying! by Microtactix, a simple and customizable generic open gaming system similar to Fuzion and the Action! System
- Skull and Crossbones - Pirate Adventures on the Spanish Main by FGU
- Skyrealms of Jorune
- SLA Industries
- Sorcerer by Ron Edwards
- Space 1889 by GDW - Victorian Era Sci-Fi (steampunk)
- Space Opera by Fantasy Games Unlimited
- Spacemaster - the SF adaptation of Rolemaster
- SpaceNinjaCyberCrisis XDO by Crucible Design - a tongue-in-cheek anime game
- Spaceship Zero by Green Ronin Publishing
- Spirit of the Century by Evil Hat Productions - a pulp game using the FATE system
- Spycraft by Alderac Entertainment Group - espionage adventure
- Star Frontiers by TSR
- StarCraft Adeventure by TSR Inc.
- StarDrive by TSR, Inc.
- Starfaring by Flying Buffalo
- Stargate SG-1 (RPG) by AEG
- Starhedge by Empire Wargames
- Star Munchkin by Steve Jackson Games
- Star Riders by Ianus Games - parody of space opera
- Starship Troopers (RPG) by Mongoose Publishing
- Star Hero - the SF adaptation of Fantasy Hero's Hero System
- Star Trek
- The Star Wars Roleplaying Game - the D6 System ancestor published by West End Games
- Star Wars - the D20 System version published Wizards of the Coast
- Star Wreck Roleplaying Game - a parody game based on the Star Wreck movie franchise, written by Mike Pohjola.
- STOCS by Wasteland Games - modern-day generic system
- Stormbringer, by Chaosium, based on Michael Moorcock's Elric of Melniboné stories
- St. Palmer's a Pirate/West Indies RPG
- Sarah superhero 2044
- Squawk - is about intelligent archosaurs in another star system, by the Game Arts Guild.
- Sundered Epoch: Generations - A multi-genre game system by Randal Snyder
- Super Squadron - an Australian Super-Hero game.
- Supernatural by Margaret Weis Productions, Ltd, based on the CW Supernatural television series.
- Superworld by Chaosium
- Swordbearer by Heritage Games and Fantasy Games Unlimited
- Sword World RPG (Japanese)
- Systems Failure by Palladium Books
- Tagmar - Brazilian fantasy game
- Tales from the Floating Vagabond by Avalon Hill
- Talislanta by Bard Games
- Teenage Mutant Ninja Turtles and Other Strangeness by Palladium Books - based on the Teenage Mutant Ninja Turtles comic books.
- Teenagers from Outer Space - an anime based RPG
- Ten Thousand Worlds - a free "universal" system distributed under a Creative Commons license
- Terra Primate by Eden Studios, Inc.
- Terra the Gunslinger (Japanese) - western and steampunk, use playing cards instead of dice
- Testament (role-playing game) by Late Gaming - game set during the End Times
- Tibet: The Roleplaying Game by Vajra Enterprises - historical fantasy set in Tibet
- Timehunter by Red Axe
- Time Lord — Adventures through Time and Space - a Doctor Who RPG based on the 1963-89 run of the BBC television series
- Timelords by Blacksburg Tactical Research Center
- Timeship by Yaquinto
- Theatrix by Backstage Press (1993)
- Tokyo NOVA (Japanese) - cyberpunk
- Toon - cartoon adventure inspired by the classic cartoon series from Warner Brothers and MGM by Steve Jackson Games
- Top Secret by TSR, Inc. - espionage adventure
- TORG by West End Games
- Transhuman Space by Steve Jackson Games
- Trauma (French) by Chroniques d'Outre-Monde - contemporary police and counter-terrorism adventures
- Travian
- Traveller by GDW, Marc Miller
- Trevas - Brazilian game about other worlds
- Tribe 8 by Dream Pod 9
- Tribes by Steve Jackson Games
- Trinity by White Wolf, Inc.
- Trystell by Tab Creations
- Tunnels and Trolls by Flying Buffalo
- TWERPS
- Twilight 2000 by GDW (1984)
- Underground by Mayfair Games
- Underworld by Synister Creative Systems Urban fantasy set in modern day New York.
- Unhallowed Metropolis by Eos Press
- Unisystem by Eden Studios, Inc.
- Universe - SF adaptation of DragonQuest
- Unknown Armies
- URPG - a free and universal RPG Rules System
- Usagi Yojimbo - based on the furry comic book series, Usagi Yojimbo, by Stan Sakai
- Valley of the Pharaohs by Palladium Books
- Vampire: The Masquerade (original World of Darkness)
- Vampire: The Requiem (World of Darkness 2.0)
- Vanishing Point (role-play game) by Sane Studios
- Via Prudensiae by Modtryk
- Villains and Vigilantes by Fantasy Games Unlimited
- Violence by Hogshead Publishing
- Warcraft the Roleplaying Game by White Wolf -- a roleplaying game book based on the popular computer game by Blizzard
- Warhammer Fantasy Roleplay by Games Workshop
- Weapons of the Gods by Eos Press - a wuxia-style game based on the manhua comic of the same name
- Weird Wars by Pinnacle Entertainment Group
- Werewolf: The Apocalypse (original World of Darkness)
- Werewolf: The Forsaken (World of Darkness 2.0)
- Westhedge by Empire Wargames
- The Wheel of Time Roleplaying Game - based on The Wheel of Time novel series by author Robert Jordan
- The Whispering Vault - an RPG about god-hunting
- Wild Talents by Arc Dream Publishing
- The Window
- Witchcraft
- Witch Hunter: The Invisible World
- World of Darkness (original) and the World of Darkness "2.0" product line by White Wolf Game Studio
- The World of Indiana Jones by West End Games
- The World of Kystrel Fantasy RPG
- Worlds of Wonder by Chaosium
- World Tree (role-playing game), roleplaying in a high-magic, highly civilized world populated by many sentient species, none of them human.
- Wraith: The Oblivion (original World of Darkness)
- Wushu
- Wuthering Heights by Philippe Tromeur, a parody of the novel Wuthering Heights
- Wytheria, The Mystic Island
- Year of the Zombie: Published by UKGames Publishing and written by Timothy Willard for the d20 Modern rule set.
- Zen and the Art of Mayhem
- Zombi by Crucible Design - Zombi schlock-horror, survival game
- Zone (French) by Siroz (satiric gang wars in the contemporary suburbs)
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